Copper, Serum (NHC)

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The Copper, Serum test measures the level of copper in the blood, an essential trace element required for the normal function of many enzymes involved in energy production, iron metabolism, nervous system function, connective tissue formation, and immune health. Abnormal copper levels may indicate disorders of copper metabolism. Increased copper levels can occur during acute inflammatory conditions, while decreased levels may be associated with Wilson’s disease, Menkes disease, nephrotic syndrome, malabsorption, malnutrition, and other metabolic disorders. The test is also useful in evaluating Primary Biliary Cirrhosis and Indian Childhood Cirrhosis.

The Copper, Serum test is recommended for individuals with suspected copper deficiency or excess, unexplained liver disease, neurological symptoms, malnutrition, or inherited copper metabolism disorders. It is also used to monitor nutritional supplementation, particularly in preterm newborns, and to assess patients receiving long-term nutritional support. Results are often interpreted together with Ceruloplasmin and other liver function tests for a comprehensive evaluation. At Nidan Pathology Lab, we provide NABL-accredited testing, FREE home sample collection, advanced laboratory technology, and accurate, timely reports to support the diagnosis and management of copper metabolism disorders.

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Copper, Serum (NHC) Test-

What is the Copper, Serum test?

The Copper, Serum test is a blood test that measures the level of copper in the bloodstream to evaluate copper metabolism and detect disorders related to copper deficiency or excess.

Why is the Copper, Serum test performed?

The test is performed to diagnose and monitor Wilson’s disease, Menkes disease, liver disorders, malnutrition, malabsorption syndromes, and other conditions affecting copper metabolism.

Who should undergo the Copper, Serum test?

The test is recommended for individuals with unexplained liver disease, neurological symptoms, suspected copper deficiency or excess, malnutrition, or inherited copper metabolism disorders, as advised by a healthcare provider.

Is fasting required before the Copper, Serum test?

Fasting is generally not required, unless specifically instructed by your healthcare provider or laboratory.

What do abnormal copper levels indicate?

High copper levels may occur in acute inflammatory conditions, liver disease, or certain metabolic disorders, while low copper levels may indicate Wilson’s disease, Menkes disease, malabsorption, nephrotic syndrome, or nutritional deficiency. Results are often interpreted together with Ceruloplasmin and other laboratory findings.

Why is the Copper, Serum test important?

The test helps diagnose copper metabolism disorders, assess nutritional status, evaluate liver function, monitor nutritional supplementation, and guide appropriate treatment and long-term management.

Introduction:

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson’s disease, Menkes disease, Primary Biliary Cirrhosis and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. They decrease in nephrosis, malabsorption and malnutrition. Copper levels are also useful to monitor patients specially preterm newborns on nutritional supplementation.

The Copper, Serum (NHC) test measures the level of copper in the blood, an essential trace mineral required for the normal function of many enzymes involved in iron metabolism, energy production, nervous system function, connective tissue formation, and immune health. The test helps evaluate copper metabolism and diagnose conditions associated with copper deficiency or excess.

Purpose of the Test:

Measure the level of copper in the blood.
Help diagnose Wilson's disease and Menkes disease.
Evaluate liver disorders and copper metabolism abnormalities.
Assess nutritional status in cases of malnutrition or malabsorption.
Monitor patients receiving nutritional supplementation, especially preterm newborns.

Symptoms:

Fatigue or weakness.
Unexplained liver problems or jaundice.
Tremors, poor coordination, or other neurological symptoms.
Poor growth or developmental delay in children.
Signs of malnutrition or recurrent infections.

Normal Range:

Adults: 70–140 µg/dL (11–22 µmol/L) (reference ranges may vary slightly between laboratories).
Copper levels may be increased in acute inflammatory conditions and decreased in disorders such as Wilson's disease, Menkes disease, malabsorption, nephrotic syndrome, or malnutrition.
Results should be interpreted along with Ceruloplasmin, liver function tests, and clinical findings.

Specification:

If Gadolinium, Iodine or Barium containing contrast media has been administered, the specimen should not be collected for 96 hours.

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