Clostridium Difficile GDH Reflex Toxin A/B by CLIA - Stool (M)

The Clostridium difficile GDH Reflex Toxin A/B by CLIA – Stool (M) test is a specialized laboratory test used to detect Clostridioides (Clostridium) difficile infection, a common cause of antibiotic-associated diarrhea and infectious colitis. The test first detects Glutamate Dehydrogenase (GDH), an enzyme produced by C. difficile. If GDH is detected, the sample is automatically tested (reflex testing) for Toxin A and Toxin B using the highly sensitive Chemiluminescent Immunoassay (CLIA) method to determine whether the bacteria are producing disease-causing toxins.

This test is recommended for patients with persistent or severe diarrhea, especially after recent antibiotic use, hospitalization, or in individuals suspected of having C. difficile infection. A fresh stool sample collected in a clean, sterile, leak-proof container is required for testing. Early and accurate detection of C. difficile toxins helps clinicians diagnose the infection promptly, initiate appropriate treatment, reduce complications, and prevent the spread of infection in healthcare settings. Test results should always be interpreted in conjunction with the patient’s symptoms and clinical history.